The medication is generally taken before anticipated sexual activity. It typically takes effect within 30 minutes to an hour, and its effects can last for several hours. Sildenafil citrate inhibits the action of PDE5, leading to an increase in the levels of cyclic guanosine monophosphate (cGMP). This, in turn, relaxes the smooth muscles in the penile blood vessels, allowing increased blood flow and facilitating an erection.
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